What Can You Do With Kief? Updated: June 8, 2025 Cannabis buds and leaves are covered in tiny crystals known as "trichomes" once they're ready for harvesting. The only way to see them is with a magnifying glass. It has a hazy appearance and resembles little mushrooms when it is fully grown. Among the cannabinoids and terpenes present are the THC that you have been eagerly anticipating. The substance known as kief is formed when trichomes dry out. Kief is a sought-after drug …